Qingpei Huang

Single-Cell full-length Isoform Sequencing Unveils Transcriptional Dysregulation in Autism Spectrum Disorder During Cerebral Cortex Development

The paper uses single-cell full-length transcriptome sequencing to study isoform regulation in developing mouse cortices, identifying dysregulated isoforms in Autism Spectrum Disorder.

Dysregulation in Spatiotemporal Expression of HMX1 Coordinated by Multifaceted Enhancers Drives an Auricular Disorder

This study identifies a CNV involving three enhancers that drive bilateral constricted ear malformations by coordinating HMX1 expression through distinct regulatory mechanisms.

Activation of a cortical neurogenesis transcriptional program during NEUROD1-induced astrocyte-to-neuron conversion

This study investigates NEUROD1-induced astrocyte-to-neuron conversion using single-cell multiomics, revealing transcriptional and epigenetic changes and comparing it to ASCL1-induced conversion.