Simon M. Hughes

The paper introduces Musclebow, a genetic lineage tracing method in zebrafish, to study myogenic precursor cell behavior during skeletal muscle development, repair, and maintenance across the lifespan.

This study shows that zebrafish desmin gene knockouts do not cause skeletal muscle degeneration but alter calcium flux in myofibers.

This study shows that Myogenin regulates adult muscle fibre growth and stem cell homeostasis by affecting myonuclear domain size, MuSC activation, and mTORC1 signaling.

The paper shows that heterozygous zebrafish mothers with an Egfra mutation are infertile, indicating a haploinsufficient maternal effect crucial for early development.

The paper shows that zebrafish muscle stem cells adjust their numbers and behavior in response to changes in fibre number, maintaining muscle size through homeostatic mechanisms.