Author

He Tian Chen

University Health NetworkORCID 0000-0001-8233-7448Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:differential expression· 1

Frequent Co-Authors

Emily TsaoiD· 2 shared Kristin J. HopeiD· 2 shared Mark David MindeniD· 2 shared Pratik JoshiiD· 2 shared Séverine CatheliniD· 2 shared Soheil JahangiriiD· 2 shared Zaldy BaldeiD· 2 shared Adam DowleiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCancer Biology

Emily TsaoORCID

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2 papers

Recent·Most cited

Cancer BiologyBloodPeer-reviewedJun 20, 2026

Aberrant splicing of MBD1 reshapes the epigenome to drive convergent myeloerythroid defects in MDS

He Tian Chen, Pratik Joshi, Séverine Cathelin…·Kristin J. Hope

This study identifies MBD1-L, an aberrantly spliced transcript in MDS, which drives epigenetic changes leading to myeloerythroid defects, and shows ASO-based targeting can restore erythroid differentiation.

2 citationstop 4%

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintJan 14, 2025

Stress Granules Underlie Acute Myeloid Leukemia Stem Cell Survival and Stress Adaptation

Amanda Tajik, Emily Tsao, Soheil Jahangiri…·Kristin J. Hope

This study identifies stress granules as critical for AML stem cell survival and stress adaptation, revealing their role in gene regulation and potential as therapeutic targets.

2 citations

humanbulk RNA-seq

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