Soheil Jahangiri

Aberrant splicing of MBD1 reshapes the epigenome to drive convergent myeloerythroid defects in MDS

This study identifies MBD1-L, an aberrantly spliced transcript in MDS, which drives epigenetic changes leading to myeloerythroid defects, and shows ASO-based targeting can restore erythroid differentiation.

Generation of Valvular Interstitial Cells from Human Pluripotent Stem Cells

This paper describes a method to generate valvular interstitial cells from human pluripotent stem cells, showing high transcriptional similarity to primary fetal VICs and recapitulating disease features in an in vitro model.

Stress Granules Underlie Acute Myeloid Leukemia Stem Cell Survival and Stress Adaptation

This study identifies stress granules as critical for AML stem cell survival and stress adaptation, revealing their role in gene regulation and potential as therapeutic targets.

Drug Sensitivity Prediction From Cell Line-Based Pharmacogenomics Data: Guidelines for Developing Machine Learning Models

This paper provides guidelines for developing machine learning models to predict drug sensitivity using cell line-based pharmacogenomics data, emphasizing proper training and validation practices.

PSL-Recommender: Protein Subcellular Localization Prediction using Recommender System

PSL-Recommender improves protein subcellular localization prediction using a recommender system, outperforming existing methods on multiple datasets.

IMMAN: an R/Bioconductor package for Interolog protein network reconstruction, Mapping and Mining ANalysis

IMMAN is an R/Bioconductor package that reconstructs interolog protein networks by integrating PPINs and enables conservation analysis across species for protein function prediction.