Madeline A. Lancaster

This study uses single-cell RNA sequencing to track the maturation of human choroid plexus organoids and identifies a stage-dependent window of developmental plasticity.

NeuroSuite provides a non-invasive platform for long-term electrophysiological monitoring of brain organoids, revealing neural network development and activity changes.

This paper introduces CtDvOPM, a microscopy technique that enables high-resolution imaging of large cleared tissues at subcellular levels without image tiling.

This study uses forebrain organoids to show that schizophrenia involves sex-specific protein-state dysregulation, with changes in post-translational modifications and proteomic pathways rather than transcript levels.

This study develops a centrifugation protocol to isolate growth cones and immature synapses from human organoids, capturing synaptic development stages and enabling models for studying synaptic function and dysfunction.

This study examines electrophysiological development and functional plasticity in dissociated human cerebral organoids across multiple cell lines, showing increasing connectivity and plasticity over time.

This study develops a method to generate forebrain organoids with macroscale geometry resembling the developing telencephalon, showing enlarged ventricles and delayed maturation in human compared to mouse.

This study compares guided and unguided forebrain organoids using multi-omic analyses, revealing differences in cellular composition, metabolic profiles, and post-translational modifications.

The paper proposes a multiscale hypothesis to explain structural differences in brain organoids derived from human versus genetically close non-human primate stem cells, linking chromatin reorganization to delayed cell fate transitions.

This study identifies factors affecting neural organoid generation by analyzing proteomic data and optimizes culture conditions to improve organoid quality.

The paper introduces a method to improve deep imaging of expanded tissues using inverted microscopes by using FEP film and water immersion objectives, achieving sub-micron resolution and 800 µm depth.

This study identifies cell-type-specific DNA methylation dynamics in the human cortex across development, highlighting prenatal periods as critical for epigenomic plasticity and linking changes to neurodevelopmental disorders.

This paper introduces a direct-view oblique plane microscopy technique for mesoscopic imaging, achieving efficient light collection and demonstrating imaging of a brain organoid.

This study identifies human-specific morphoregulatory signatures in basal radial glia that drive neocortex evolution through comparative chromatin and transcriptional profiling.

The paper shows that slower axon growth in humans, driven by reduced calcium influx, leads to longer axon tracts through prolonged growth duration, with calcium dynamics regulating developmental timing.

This study identifies histone modification fluctuations as a cause of PSC differentiation bias and presents a chemical chromatin restoration method to reverse it, restoring epiblast-like differentiation potential.

This study develops protocols for generating mouse brain organoids that mimic in vivo neurodevelopment and function, showing they closely resemble in vivo models across multiple readouts.

MEA-NAP analyzes microscale functional connectivity and network dynamics from MEA recordings in neuronal cultures, revealing differences in topology and network development.

The paper examines sex differences in brain structure at birth in newborns, finding larger brain volumes in males and specific regional differences in gray and white matter volumes between sexes.

This study develops a cerebellar organoid model to compare development across species and identifies species-specific size differences and gene expression patterns.

This study presents a temporal atlas of protein and PTM abundance in cerebral organoids, showing significant changes during development related to neuronal differentiation and energy metabolism.

This study demonstrates circadian rhythms in human brain cells and organoids, showing they are temperature-compensated and modulated by drugs and cortisol, with implications for chronobiology and brain health.

The paper shows that CBP/EP300 acetylates and stabilizes HSF2, which is disrupted in Rubinstein-Taybi syndrome, leading to impaired heat shock response.

GWAS of 2,347 neuroimaging phenotypes identifies genetic loci and structures related to cortical development, cellular processes, and neurodevelopmental disorders.

This study identifies genetic correlates of phenotypic heterogeneity in autism by analyzing common and de novo variants across core features and co-occurring disabilities.

The paper uses single-cell RNA sequencing to study genetic variant effects on dopaminergic neuron differentiation from iPSCs, identifying eQTL and cell fate markers.

This study uses brain organoids to show that male sex hormones increase excitatory neuron production in the human neocortex by enhancing progenitor proliferation and affecting chromatin remodeling.

This study shows SARS-CoV-2 infects choroid plexus epithelial cells in brain organoids, disrupts the blood-CSF barrier, and may contribute to neurological complications.

This study shows that cerebral organoids cultured at the air-liquid interface form functional nerve tracts with diverse morphologies and connectivity.