Pia Jensen

STEP-PTM enables integrated quantitative analysis of proteome, metabolome, and multiple PTM classes from single biological samples using a modular TMT-multiplexed workflow.

This study uses forebrain organoids to show that schizophrenia involves sex-specific protein-state dysregulation, with changes in post-translational modifications and proteomic pathways rather than transcript levels.

This study uses patient-derived organoids to identify synaptic protein and phospho-regulatory deficits in schizophrenia.

This study uses brain organoids to show that miRNA dysregulation in schizophrenia leads to premature GABAergic maturation and neurodevelopmental defects.

This study develops a centrifugation protocol to isolate growth cones and immature synapses from human organoids, capturing synaptic development stages and enabling models for studying synaptic function and dysfunction.

This study compares guided and unguided forebrain organoids using multi-omic analyses, revealing differences in cellular composition, metabolic profiles, and post-translational modifications.

This study identifies factors affecting neural organoid generation by analyzing proteomic data and optimizes culture conditions to improve organoid quality.

This study presents a temporal atlas of protein and PTM abundance in cerebral organoids, showing significant changes during development related to neuronal differentiation and energy metabolism.

This study identifies angiotensin-(1-5) as a potent endogenous agonist of the AT2-receptor, showing its ability to increase nitric oxide release and lower blood pressure through AT2R-mediated mechanisms.

This study uses a novel proteomics platform to identify PTM dysregulation in GBA-N370S PD neurons, revealing impaired neuritogenesis and a role for tau.

The paper identifies Golgi fragmentation as an early AD phenotype in neurons using stem cell and mouse models, showing its link to SORL1 variants and glycosylation changes.

This study identifies site-specific changes in sialylation of N-linked glycoproteins in rat nerve terminals following brief depolarization.