Author

Alexandre Puissant

Centre National de la Recherche ScientifiqueORCID 0000-0002-3997-9282Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Aarthi Nivasini MaheshiD· 1 shared Ahmed M. MamdouhiD· 1 shared Amy E. StewartiD· 1 shared Ben Zolyomi· 1 shared Brandon Douglas BrowniD· 1 shared Camille LobryiD· 1 shared Cheryl Gek Teng Chan· 1 shared Christopher B. NewgardiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Aarthi Nivasini MaheshORCID

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2 papers

Recent·Most cited

BIRC5 dependency defines a targetable vulnerability in TP53 mutant acute myeloid leukemia

Ahmed M. Mamdouh, Fang Qi Lim, Yang Mi, Elyse A. Olesinski, Shaista Shabbir Jasdanwala, Xiao Xian Lin, Edward Ayoub, Jordan Yong Ming Tan, Karanpreet Singh Bhatia, Yichen Wang, Shradha Garnaik, Kunal Tomar, Valeriia Sapozhnikova, Cheryl Gek Teng Chan, Chuqi Wang, , Shruti Bhatt

This study identifies BIRC5 as a targetable vulnerability in TP53 mutant AML, showing that survivin/IAP inhibitors can overcome therapy resistance.

bioRxiv · May 17, 2025 · PreprintCancer Biology

Pathway Coessentiality Mapping Reveals Complex II is Required for de novo Purine Biosynthesis in Acute Myeloid Leukemia

Amy E. Stewart, Derek K. Zachman, Pol Castellano‐Escuder, Lois M. Kelly, Ben Zolyomi, Michael D. I. Aiduk, Christopher D. Delaney, Ian C. Lock, Claudie Bosc, John Bradley, Shane T. Killarney, Olga Ilkayeva, Christopher B. Newgard, Navdeep S. Chandel, Alexandre Puissant, , Matthew D. Hirschey

The paper identifies Complex II's role in de novo purine biosynthesis in AML using CRISPR and metabolomic data, showing it as a therapeutic target.

bioRxiv · Feb 26, 2025 · PreprintCancer Biology