Pathway Coessentiality Mapping Reveals Complex II is Required for de novo Purine Biosynthesis in Acute Myeloid Leukemia
Amy E. Stewart, Derek K. Zachman, Pol Castellano‐Escuder, Lois M. Kelly, Ben Zolyomi, Michael D. I. Aiduk, Christopher D. Delaney, Ian C. Lock, Claudie Bosc, John Bradley, Shane T. Killarney, Olga Ilkayeva, Christopher B. Newgard, Navdeep S. Chandel, Alexandre Puissant, , Matthew D. Hirschey
The paper identifies Complex II's role in de novo purine biosynthesis in AML using CRISPR and metabolomic data, showing it as a therapeutic target.
bioRxiv · Feb 26, 2025 · PreprintCancer Biology