Author

Jens Høiriis Nielsen

University of CopenhagenORCID 0000-0001-8252-3048Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Bo Torben PorseiD· 1 shared Guy A. RutteriD· 1 shared Lorenzo PiemontiiD· 1 shared Piero MarchettiiD· 1 shared Seyed Mojtaba GhiasiiD· 1 shared Thomas R Mandrup-PoulseniD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperCell Biology

Bo Torben PorseORCID

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1 paper

Recent·Most cited

Cell BiologyFrontiers in EndocrinologyPeer-reviewedMar 22, 2024

Proinflammatory Cytokines Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells

Seyed Mojtaba Ghiasi, Piero Marchetti, Lorenzo Piemonti…·Guy A. Rutter

This study shows proinflammatory cytokines suppress NMD activity in β-cells by downregulating UPF3B, leading to increased alternative splicing and ECM-related gene expression, which contributes to β-cell dysfunction.

6 citations

humanrat

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