Bo Torben Porse

This study identifies cholesterol biosynthesis as a therapeutic target in CEBPA-mutant AML, showing that statins enhance chemosensitivity in cells with co-mutations in TET2 or WT1.

This paper introduces AbTags, a method to enhance detection of low-abundant proteins in single-cell proteomics by mass spectrometry through antibody-based signal amplification.

The paper integrates single-cell proteomics and transcriptomics to study human hematopoietic stem and progenitor cells, identifying protein markers and dynamics not captured by mRNA alone.

The paper introduces iDIA, a method that enhances sensitivity for quantifying regulatory proteins in single cells, revealing lineage priming and cell-cycle coordination in hematopoietic stem and progenitor cells.

This study evaluates the Orbitrap Astral MS's sensitivity for single-cell proteomics, showing improved proteome coverage and quantitative accuracy in low-input samples.

This study develops a low-input proteomics workflow to analyze rare hematopoietic stem and progenitor cells, identifying 7,000 proteins and a novel marker for long-term hematopoietic stem cells.

This study evaluates the Astral mass analyzer's performance in single-cell proteomics using DIA, showing improved proteome depth and quantitative precision for ultra-low input samples.

The paper develops a tailored DIA method for single-cell proteomics to improve quantification from low-input samples and establishes a complete scp-MS workflow.

The paper presents a workflow for single-cell proteomics to study cellular heterogeneity in leukemia, demonstrating the ability to quantify thousands of proteins per cell.