Jeong Seok Lee

This study shows fructose metabolism in GM-CSF-differentiated macrophages promotes autoimmune inflammation through MG-AGE-RAGE signaling by enhancing glycolysis and Th17 differentiation.

This study compares target-enhanced whole-genome sequencing (TE-WGS) with a commercial targeted panel, showing TE-WGS detects all variants and provides additional clinical insights.

The paper uses whole-genome sequencing to determine zygotic composition in chimeric twins, finding asymmetrical contributions from two zygotes in blood but not in buccal tissues.

This paper introduces RUN-DVC, a semi-supervised training method for deep variant callers that improves generalization across sequencing methods with varying error profiles.

The paper identifies trained immunity in AS monocytes and shows their enhanced response to T-cell activation, contributing to Th17 responses and disease pathology.