Liye Chen

This study identifies CD4+ tissue-resident memory Th17 (TRM17) cells as the main source of IL-17A in SpA synovium, showing their role in disease pathology and potential as therapeutic targets.

This study compares T-cell-driven IL-1β production in humans and mice, finding distinct molecular mechanisms involving different signaling pathways and enzymes.

This study profiles CD8+ T cells in AxSpA synovium using scRNA-seq, identifying HLA-DR+ TRM and KIR+ subsets with distinct transcriptional features and potential pathogenic roles.

The paper identifies trained immunity in AS monocytes and shows their enhanced response to T-cell activation, contributing to Th17 responses and disease pathology.

The paper identifies genetic variants and HLA types associated with susceptibility to enteric fever in human volunteers challenged with Salmonella.

The paper investigates how a polymorphism in a RUNX3 enhancer affects TF binding in CD8+ T-cells, linking it to ankylosing spondylitis risk.