NeuroscienceProceedings of the National Academy of SciencesPeer-reviewed
Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation
Desi C. Alexander, Tanya S. Corman, Mariel R. Mendoza…·Shelley L. Berger
This study shows that inhibiting Acss2 reduces fear memory formation and anxiety in mice and rats by decreasing histone acetylation and gene expression in the hippocampus.