Gabor Egervári

This study identifies ACSS2 as a mediator of prenatal alcohol exposure-related phenotypes, showing its role in histone acetylation and developmental changes in the brain.

The paper shows the ketogenic diet reduces excitatory synaptic gain by shrinking synaptic vesicle pools through transcriptional and epigenetic changes in the hippocampus.

This study shows that Acss2 knockout mice consume less alcohol and exhibit epigenetic and transcriptional changes in the ventral striatum, particularly in males.

This study shows acetate improves spatial memory in female mice via sex- and brain region-specific epigenetic and transcriptional changes in the dorsal hippocampus.

This study shows ACSS2-mediated histone acetylation is critical for learning and memory in a mouse AD model, with acetate supplementation rescuing deficits.

This study shows that inhibiting Acss2 reduces fear memory formation and anxiety in mice and rats by decreasing histone acetylation and gene expression in the hippocampus.

This study identifies spurious intragenic transcription as a conserved hallmark of mammalian cellular senescence and tissue aging, impacting cellular health and transcriptional networks.