Author

Desi C. Alexander

University of PennsylvaniaORCID 0000-0001-8715-2004Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Shelley L. BergeriD· 4 shared Connor HoganiD· 3 shared Gabor EgerváriiD· 3 shared Greg DonahueiD· 3 shared Benjamin Aaron GarciaiD· 2 shared Mariel R. MendozaiD· 2 shared Nancy M. BoniniiD· 2 shared Andrew Glass· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Shelley L. BergerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration

Naemeh Pourshafie, Desi C. Alexander, Hong Wei Xu, Kechun Yang, Greg Donahue, Xue Lei, Shuo Zhang, Oksana Shcherbakova, Connor Hogan, Michael Gilbert, Kevt’her Hoxha, Lesley S. Chaboub, Virginia M.‐Y. Lee, Peter D. Adams, John A. Dani, , Shelley L. Berger

This study shows that increasing ACSS2 levels protects neurons from age-related and tau-induced decline by enhancing synaptic and longevity gene expression.

Proceedings of the National Academy of Sciences · Jan 9, 2026Peer-reviewedNeuroscience

Decreased voluntary alcohol intake and ventral striatal epigenetic and transcriptional remodeling in male Acss2 KO mice

Gabor Egervári, Greg Donahue, Natalia A. Quijano Cardé, Desi C. Alexander, Connor Hogan, Jessica K. Shaw, Erica M. Periandri, Vanessa Fleites, Mariella De Biasi, Shelley L. Berger

This study shows that Acss2 knockout mice consume less alcohol and exhibit epigenetic and transcriptional changes in the ventral striatum, particularly in males.

Neuropharmacology · Dec 9, 2024Peer-reviewedNeuroscience

ACSS2 contributes to transcriptional regulation in Cajal-Retzius cells in a mouse model of Alzheimer's disease

Gabor Egervári, Desi C. Alexander, Greg Donahue, Hua Huang, Connor Hogan, Mariel R. Mendoza, Benjamin Aaron Garcia, Nancy M. Bonini, Shelley L. Berger

This study shows ACSS2-mediated histone acetylation is critical for learning and memory in a mouse AD model, with acetate supplementation rescuing deficits.

bioRxiv · Apr 8, 2024 · PreprintNeuroscience

Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation

Desi C. Alexander, Tanya S. Corman, Mariel R. Mendoza, Andrew Glass, Tal Belity, Ranran Wu, Rianne R. Campbell, Joseph Han, Ashley A. Keiser, Jeffrey D. Winkler, Marcelo A. Wood, Thomas Kim, Benjamin Aaron Garcia, Hagit Cohen, Philipp Mews, , Shelley L. Berger

This study shows that inhibiting Acss2 reduces fear memory formation and anxiety in mice and rats by decreasing histone acetylation and gene expression in the hippocampus.

Proceedings of the National Academy of Sciences · Aug 3, 2022Peer-reviewedNeuroscience