Sharon N. Edmiston

This study shows that chromatin architecture and physical constriction together drive phenotype switching and metastasis in melanoma by altering CTCF positioning and heterochromatin structure.

The paper improves somatic mutation detection in tumor samples without matched normal samples by estimating tumor purity and variant allele frequency, reducing false positive and negative rates.

CellGate automates spatial immunophenotyping of multiplexed tissue images with high accuracy, enabling scalable analysis of tumor-immune microenvironments.