Nancy E. Thomas

Folate metabolism in tumor-associated macrophages drives immunosuppressive function to promote tumor growth

This study identifies folate receptor beta (FRβ) as a metabolic checkpoint on tumor-associated macrophages (TAMs) that promotes immunosuppression and tumor growth.

Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination

This study shows that chromatin architecture and physical constriction together drive phenotype switching and metastasis in melanoma by altering CTCF positioning and heterochromatin structure.

Improving Accuracy of Somatic Mutation Profiling in Large Epidemiologic Studies: Addressing Cases without Matched Normal Samples

The paper improves somatic mutation detection in tumor samples without matched normal samples by estimating tumor purity and variant allele frequency, reducing false positive and negative rates.

Spatial Immunophenotyping from Whole-Slide Multiplexed Tissue Imaging Using Convolutional Neural Networks

CellGate automates spatial immunophenotyping of multiplexed tissue images with high accuracy, enabling scalable analysis of tumor-immune microenvironments.