James William Smithy

This study identifies PD-L2's role on dendritic cells in restraining CD8+ T cell immunity in tumors, showing distinct functions from PD-L1 and suggesting therapeutic implications for PD-L2 blockade.

The paper introduces SpatialTopic, a Bayesian topic model for multiplexed imaging analysis that identifies spatial features and tracks their dynamics across disease progression.

CellGate automates spatial immunophenotyping of multiplexed tissue images with high accuracy, enabling scalable analysis of tumor-immune microenvironments.