Paul Guilhamon

This study identifies SAT1 as a key driver of quiescence in glioblastoma stem cells through metabolic rewiring and viral mimicry, showing it can induce reversible growth arrest.

SMuRF identifies genomic regions enriched for somatic point mutations in user-defined intervals using SNVs from liver cancer data.

C3D predicts 3D genomic interactions between cis-regulatory elements using DNA accessibility correlations, achieving 32.7% accuracy in K562 cells.

This study identifies metabolic adaptations in taxane-resistant triple-negative breast cancer cells that lead to epigenetic vulnerabilities, specifically through altered methionine metabolism and H3K27me3 redistribution.