ImmunologybioRxivPreprint
Cytokine-Induced Cell Exhaustion to Mitigate Hyperinflammation
Tommaso Marchetti, Samantha Milanesi, Diana Tintor…·Jana Pachlopnik Schmid
This study shows that targeted IL-2 treatment reduces hyperinflammation in a perforin-deficient mouse model of HLH by inducing CD8+ T cell exhaustion.
DOI 10.1101/2024.08.12.607544