Cytokine-Induced Cell Exhaustion to Mitigate Hyperinflammation
Tommaso Marchetti, Samantha Milanesi, Diana Tintor, Tiziana Lorenzini, Severin Walser, Stefano Vavassori, Onur Boyman, Jana Pachlopnik Schmid
This study shows that targeted IL-2 treatment reduces hyperinflammation in a perforin-deficient mouse model of HLH by inducing CD8+ T cell exhaustion.
bioRxiv · Aug 12, 2024 · PreprintImmunology