Dynamics of natural selection preceding human viral epidemics and pandemics.
Jennifer L. Havens, Sergei L. Kosakovsky Pond, Jordan D. Zehr…·Joel O. Wertheim
The paper uses phylogenetic analysis to examine natural selection in zoonotic viruses, finding no evidence of pre-zoonotic adaptation for human transmission but detecting selection changes in the 1977 H1N1 reemergence.