Simultaneous broad protection against Ebola Sudan, Marburg and Lassa viruses conferred by a DNA primed MVA-vectored multivalent vaccine
Darwyn Kobasa, Martina Pfranger, Nina Krause…·Jonathan Luke Heeney
Author
Harvard UniversityORCID 0000-0002-3056-6705Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Darwyn Kobasa, Martina Pfranger, Nina Krause…·Jonathan Luke Heeney
Patrick Varilly, Mark Schifferli, Katherine Y. Yang…·Pardis Christine Sabeti
Delphy provides a fast, scalable Bayesian phylogenetic analysis tool for outbreak tracking, achieving 1,000x speedups while maintaining state-of-the-art accuracy.
Yvan Butera, Léon Mutesa, Edyth Parker…·Claude Mambo Muvunyi
The paper uses genomic analysis to show the Rwanda MVD outbreak originated from a single zoonotic event with limited human-to-human transmission.
Anise N. Happi, Olusola Akinola Ogunsanya, Judith Uche Oguzie…·Christian Tientcha Happi
The paper reports the first genomic characterization of RHDV2 in sub-Saharan Africa using metagenomic sequencing and identifies genetic diversity in GI.2 strains.
Kayla G. Barnes, Anna E. Lachenauer, Adam D. Nitido…·Pardis Christine Sabeti
This paper develops CRISPR-Cas13a-based diagnostics for real-time detection of Ebola and Lassa viruses in field settings, demonstrating sensitivity and usability in clinical samples.
Idowu B. Olawoye, Simon D. W. Frost, Christian Tientcha Happi
This study analyzes the pan-genome of Mycobacterium africanum and related lineages to explore their evolutionary dynamics and geographic distribution.
Fehintola Victoria Ajogbasile, Judith Uche Oguzie, Paul E. Oluniyi…·Christian Tientcha Happi
The paper uses metagenomic sequencing to identify a yellow fever outbreak in Edo State, Nigeria, from undiagnosed fever cases.
Hayden C. Metsky, Katherine J. Siddle, Adrianne D. Gladden…·Christian B. Matranga
The paper introduces CATCH, a method for designing compact and scalable probe sets to enhance metagenomic sequencing sensitivity, demonstrating improved viral genome recovery and diversity preservation.