Zhihao Guo

The paper identifies a shared A-to-G and G-to-A substitution bias in nanopore sequencing, amplified by bacterial DNA methylation, and shows this bias is concentrated around methylation motifs.

The paper evaluates RNA modification detection in E. coli using nanopore RNA004 technology, introduces nanoSundial for improved detection, and identifies 190 modified CDS regions.

This study uses direct RNA sequencing to compare TGEV with and without gene 7, revealing changes in RNA modifications and polyA tails, and their impact on viral replication and host immunity.

This study maps pseudouridine modifications across bacterial species, revealing dynamic patterns and evolutionary conservation, and develops a deep learning framework for predicting modified sites.

Giraffe is a tool for comparative analysis and visualization of long-read sequencing data across multiple samples and platforms, showing Oxford Nanopore duplex reads outperform PacBio HiFi in homopolymer identification and GC evenness.