Pericytes regulate vascular immune homeostasis in the CNS
Orsolya Török, Bettina Schreiner, Johanna Schaffenrath, Hsing‐Chuan Tsai, Upasana Maheshwari, Sebastian A. Stifter, Christina A. Welsh, Ana Amorim, Sucheta Sridhar, Sebastian G. Utz, Wiebke Mildenberger, Sina Nassiri, Mauro Delorenzi, Adriano Aguzzi, May Htwe Han, , Annika Keller
This study shows that pericytes restrict immune cell entry into the CNS by maintaining immune quiescence of brain endothelial cells, and their deficiency leads to increased leukocyte infiltration and severe neuroinflammation.
Proceedings of the National Academy of Sciences · Mar 2, 2021Peer-reviewedNeuroscience