Sucheta Sridhar

This study identifies spatial and dynamic molecular heterogeneity in adult mouse brain pericytes across anatomical regions, vascular positions, aging, ischemia, and circadian phases.

This study shows that pericytes restrict immune cell entry into the CNS by maintaining immune quiescence of brain endothelial cells, and their deficiency leads to increased leukocyte infiltration and severe neuroinflammation.

This study shows microglia control vessel calcification via TREM2, with ablation worsening calcification and revealing a new role in preventing ectopic calcification.