Upasana Maheshwari

Brain pericytes exhibit spatially organized and dynamically regulated molecular heterogeneity

This study identifies spatial and dynamic molecular heterogeneity in adult mouse brain pericytes across anatomical regions, vascular positions, aging, ischemia, and circadian phases.

Hippocampal purinergic P2X7 receptor level is increased in Alzheimer's disease patients, and associated with amyloid and tau pathologies

The paper examines increased P2X7R levels in Alzheimer's disease hippocampi, correlating with amyloid and tau pathologies, and identifies its potential as a neuroinflammation marker.

Aquaporin 4 is differentially increased and depolarized in association with tau and amyloid-beta

The paper investigates AQP4 distribution and depolarization in tau and amyloid-beta pathologies using mouse models and imaging techniques.

Pericytes regulate vascular immune homeostasis in the CNS

This study shows that pericytes restrict immune cell entry into the CNS by maintaining immune quiescence of brain endothelial cells, and their deficiency leads to increased leukocyte infiltration and severe neuroinflammation.

An evolutionarily conserved Lhx2-Ldb1 interaction regulates the acquisition of hippocampal cell fate and regional identity

The paper shows that the Lhx2-Ldb1 interaction is conserved in regulating hippocampal development and cell fate in mice.

Microglia control small vessel calcification via TREM2

This study shows microglia control vessel calcification via TREM2, with ablation worsening calcification and revealing a new role in preventing ectopic calcification.

A Hox code defines spinocerebellar neuron subtype regionalisation

The paper identifies a Hox code that defines molecular regionalisation of spinocerebellar neuron subtypes in the cervico-thoracic spinal cord.