BioengineeringbioRxivPreprint
Title: Optogenetic WNT signaling drives germ layer self-organization in a human gastruloid model
Hunter J. Johnson, David M. McMullin, Joshua A. Zimmermann…·David V. Schaffer
The paper uses optogenetic WNT activation in human gastruloids to study germ layer self-organization and finds it drives mesendoderm differentiation and patterning.
DOI 10.64898/2026.02.23.707602