Author

Sedona E. Murphy

Stanford UniversityORCID 0000-0001-8345-1955Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:ChIP-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:spatial domain detection· 2 Research Focus:differential expression· 1 Assay:Hi-C· 1 Organism:mouse· 1

Frequent Co-Authors

Alistair Nicol BoettigeriD· 3 shared Howard Y. ChangiD· 2 shared Katerina KraftiD· 2 shared Aarohi Bhargava-ShahiD· 1 shared Andreas MaggiD· 1 shared Britney Jiayu HeiD· 1 shared Christy LuongiD· 1 shared Jef D. BoekeiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersGenetics

Alistair Nicol BoettigerORCID

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3 papers

Recent·Most cited

GeneticsNature Cell BiologyPeer-reviewedOct 21, 2025

Enhancer activation from transposable elements in extrachromosomal DNA

Katerina Kraft, Sedona E. Murphy, Matthew G. Jones…·Howard Y. Chang

The paper identifies enhancer-like elements on ecDNA in colorectal cancer that are derived from transposable elements and are functionally active in cancer cell fitness.

20 citationstop 1%

humanexperimental assay

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Molecular BiologybioRxivPreprintOct 14, 2022

Polycomb repression of Hox genes involves spatial feedback but not domain compaction or demixing

Sedona E. Murphy, Alistair Nicol Boettiger

The paper challenges the repression-by-compaction model of Polycomb proteins by showing that PcG-bound chromatin remains repressed while exploring decompact states and mixing with neighboring chromatin.

6 citations

humanChIP-seq

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GeneticsProceedings of the National Academy of SciencesPeer-reviewedMay 26, 2022

Polycomb-mediated Genome Architecture Enables Long-range Spreading of H3K27 methylation

Katerina Kraft, Kathryn E. Yost, Sedona E. Murphy…·Howard Y. Chang

The paper investigates how Polycomb-mediated genome architecture facilitates long-range H3K27 methylation spreading in ESCs and iPSCs, revealing RNA-dependent DNA looping and developmental gene roles in chromatin organization.

110 citationstop 1%

mousehuman

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