Author

Aarohi Bhargava-Shah

Stanford MedicineORCID 0000-0001-7404-5146Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Howard Y. ChangiD· 2 shared Jens LuebeckiD· 2 shared Katerina KraftiD· 2 shared King L. HungiD· 2 shared Matthew G. JonesiD· 2 shared Paul S. MischeliD· 2 shared Quanming ShiiD· 2 shared Rui LiiD· 2 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Howard Y. ChangORCID

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Author profile →

3 papers

Recent·Most cited

Enhancer activation from transposable elements in extrachromosomal DNA

Katerina Kraft, Sedona E. Murphy, Matthew G. Jones, Quanming Shi, Aarohi Bhargava-Shah, Christy Luong, King L. Hung, Britney Jiayu He, Rui Li, Seung Kuk Park, Michael T. Montgomery, Natasha E. Weiser, Yanbo Wang, Jens Luebeck, Vineet Bafna, , Howard Y. Chang

The paper identifies enhancer-like elements on ecDNA in colorectal cancer that are derived from transposable elements and are functionally active in cancer cell fitness.

Nature Cell Biology · Oct 21, 2025Peer-reviewedGenetics

EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs

Hyerim Yi, Shu Zhang, Jason T. Swinderman, Yanbo Wang, Vishnupriya Kanakaveti, King L. Hung, Ivy Tsz-Lo Wong, Suhas Srinivasan, Ellis J. Curtis, Aarohi Bhargava-Shah, Rui Li, Matthew G. Jones, Jens Luebeck, Yanding Zhao, Julia A. Belk, , Howard Y. Chang

The paper shows that ecDNA-borne PVT1 fusions stabilize oncogenic mRNAs by interacting with SRSF1, enhancing RNA stability and supporting MYC dependency in cancer.

bioRxiv · Apr 1, 2025 · PreprintCancer Biology

A stable mode of bookmarking by TBP recruits RNA Polymerase II to mitotic chromosomes

Sheila S. Teves, Luye An, Aarohi Bhargava-Shah, Liangqi Xie, Xavier Darzacq, Robert Tjian

The paper shows TBP remains bound to promoters during mitosis, stabilizing RNA Polymerase II association and enabling transcriptional reactivation.

eLife · Jun 25, 2018Peer-reviewedMolecular Biology