Author

Rebecca M. Fleeman

Pennsylvania State UniversityORCID 0000-0001-8346-7922Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 5 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Organism:mouse· 3 Organism:human· 2 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Elizabeth A. ProctoriD· 5 shared Madison K. KuhniD· 4 shared Brendan K. BalliD· 2 shared Dennis C. ChaniD· 2 shared Douglas K. BrubakeriD· 2 shared Amanda M. SnyderiD· 1 shared Gina M. Deiter· 1 shared Kristen N. Lambert· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersSystems Biology

Elizabeth A. ProctorORCID

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5 papers

Recent·Most cited

Systems BiologyBrain ResearchPeer-reviewedJul 4, 2025

Metabolites associated with type 2 diabetes and Alzheimer's disease trigger differential intracellular signaling responses in mouse primary neurons

Brendan K. Ball, Madison K. Kuhn, Rebecca M. Fleeman…·Douglas K. Brubaker

The paper investigates how metabolites linked to type 2 diabetes and Alzheimer's disease affect intracellular signaling in mouse neurons, identifying specific pathway activations associated with disease progression or protection.

1 citation

mouseproteomics

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Systems BiologyScientific ReportsPeer-reviewedJun 3, 2024

Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer's disease-associated metabolites

Brendan K. Ball, Madison K. Kuhn, Rebecca M. Fleeman…·Douglas K. Brubaker

The paper investigates how primary neurons respond to metabolites linked to type 2 diabetes and Alzheimer's disease, identifying differential secretion of MCP-1 and IL-9.

15 citations

mousebulk RNA-seq

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NeurosciencebioRxivPreprintApr 7, 2023

Alzheimer's disease-specific cytokine secretion suppresses neuronal mitochondrial metabolism

Madison K. Kuhn, Rebecca M. Fleeman, Lynne M. Beidler…·Elizabeth A. Proctor

This study identifies an Alzheimer's disease-specific cytokine signature that suppresses mitochondrial function in neurons, linking neuroinflammation to metabolic dysfunction.

4 citations

mousebulk RNA-seq

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NeurosciencebioRxivPreprintSep 29, 2022

Apolipoprotein E4 modulates astrocyte neuronal support functions in the presence of amyloid-β

Rebecca M. Fleeman, Madison K. Kuhn, Dennis C Chan, Elizabeth A. Proctor

This study shows that APOE4 astrocytes increase neuronal metabolic stress in the presence of amyloid-β compared to APOE3 astrocytes.

1 citation

humanbulk RNA-seq

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Systems BiologybioRxivPreprintJun 26, 2020

Novel microRNA multivariate biomarkers of response to immunotherapy against HPV E6 oncogene

Rebecca M. Fleeman, Gina M. Deiter, Kristen N. Lambert…·Rébécca Phaëton

The paper identifies miR signatures modulated by anti-HPV E6 mAbs that predict response to treatment in cervical cancer models.

DOI 10.1101/2020.06.26.174441

humanstatistical model

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