Author

Madison K. Kuhn

Pennsylvania State UniversityORCID 0000-0001-9407-6249Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 5 Approach:statistical model· 5 Assay:bulk RNA-seq· 4 Organism:mouse· 4 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Elizabeth A. ProctoriD· 6 shared Rebecca M. FleemaniD· 4 shared Dennis Chun Yin ChaniD· 3 shared Brendan K. BalliD· 2 shared ChaeMin KimiD· 2 shared Douglas K. BrubakeriD· 2 shared Lynne M. Beidler· 2 shared Rachel Y. KangiD· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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6 shared papersNeuroscience

Elizabeth A. ProctorORCID

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6 papers

Recent·Most cited

Systems BiologyBrain ResearchPeer-reviewedJul 4, 2025

Metabolites associated with type 2 diabetes and Alzheimer's disease trigger differential intracellular signaling responses in mouse primary neurons

Brendan K. Ball, Madison K. Kuhn, Rebecca M. Fleeman…·Douglas K. Brubaker

The paper investigates how metabolites linked to type 2 diabetes and Alzheimer's disease affect intracellular signaling in mouse neurons, identifying specific pathway activations associated with disease progression or protection.

1 citation

mouseproteomics

𝕏 PostBluesky

Systems BiologyScientific ReportsPeer-reviewedJun 3, 2024

Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer's disease-associated metabolites

Brendan K. Ball, Madison K. Kuhn, Rebecca M. Fleeman…·Douglas K. Brubaker

The paper investigates how primary neurons respond to metabolites linked to type 2 diabetes and Alzheimer's disease, identifying differential secretion of MCP-1 and IL-9.

15 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintMar 17, 2024

Cytokine expression patterns predict suppression of vulnerable neural circuits in a mouse model of Alzheimer's disease

Dennis Chun Yin Chan, ChaeMin Kim, Rachel Y. Kang…·Elizabeth A. Proctor

The paper identifies immune signatures predicting changes in neural circuit activity in a mouse Alzheimer's model.

1 citation

mousespatial transcriptomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 16, 2023

Dynamic neuroinflammatory profiles predict Alzheimer's disease pathology in microglia-containing cerebral organoids

Madison K. Kuhn, Rachel Y. Kang, ChaeMin Kim…·Elizabeth A. Proctor

This study uses AD organoids to identify dynamic neuroinflammatory profiles and their impact on neuronal health and microglial function.

8 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 7, 2023

Alzheimer's disease-specific cytokine secretion suppresses neuronal mitochondrial metabolism

Madison K. Kuhn, Rebecca M. Fleeman, Lynne M. Beidler…·Elizabeth A. Proctor

This study identifies an Alzheimer's disease-specific cytokine signature that suppresses mitochondrial function in neurons, linking neuroinflammation to metabolic dysfunction.

4 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintSep 29, 2022

Apolipoprotein E4 modulates astrocyte neuronal support functions in the presence of amyloid-β

Rebecca M. Fleeman, Madison K. Kuhn, Dennis C Chan, Elizabeth A. Proctor

This study shows that APOE4 astrocytes increase neuronal metabolic stress in the presence of amyloid-β compared to APOE3 astrocytes.

1 citation

humanbulk RNA-seq

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