Author

Van A. Ngo

Oak Ridge National LaboratoryORCID 0000-0001-8350-1203Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Lei ShiiD· 2 shared Alem W. KahsaiiD· 1 shared Alex Rojas Bie ThomseniD· 1 shared Ali MasoudiiD· 1 shared Allison M. SchwalbiD· 1 shared Anand ChundiiD· 1 shared Bowie N. ShreiberiD· 1 shared Brittany N. ThomasiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Lei ShiORCID

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2 papers

Recent·Most cited

BiochemistryNaturePeer-reviewedJun 24, 2026

Small-molecule modulation of Beta-arrestins

Alem W. Kahsai, Natalia Pakharukova, Henry Y. Kwon…·Robert J. Lefkowitz

This study identifies small-molecule inhibitors of beta-arrestins and elucidates their mechanism, offering a framework for modulating GPCR signaling.

7 citationstop 2%

humanproteomics

𝕏 PostBluesky

BiophysicsbioRxivPreprintJun 10, 2025

Conformational dynamics of the active state of β-arrestin 1

Van A. Ngo, Wesley B. Asher, Jonathan A. Javitch, Lei Shi

This study uses molecular dynamics simulations to investigate the conformational changes in β-arrestin 1 during activation by the vasopressin receptor-2.

DOI 10.1101/2025.06.10.658911

protein structurebiophysical modeling

𝕏 PostBluesky