Author

Brittany N. Thomas

Duke Medical CenterORCID 0000-0001-8317-7538Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Alem W. KahsaiiD· 2 shared Dana K. BassfordiD· 2 shared Jihee Kim· 2 shared Natalia PakharukovaiD· 2 shared Robert J. LefkowitziD· 2 shared Seungkirl AhniD· 2 shared Xingdong Zhang· 2 shared Alex Rojas Bie ThomseniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Alem W. KahsaiORCID

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2 papers

Recent·Most cited

Small-molecule modulation of Beta-arrestins

Alem W. Kahsai, Natalia Pakharukova, Henry Y. Kwon, Kunal S. Shah, Caroline T. del Real, Bowie N. Shreiber, Jason G. Liang-Lin, Paul J. Shim, Mason A. Lee, Van A. Ngo, Allison M. Schwalb, Uyen Pham, Anand Chundi, Haoran Jiang, Emmanuel Flores-Espinoza, , Robert J. Lefkowitz

This study identifies small-molecule inhibitors of beta-arrestins and elucidates their mechanism, offering a framework for modulating GPCR signaling.

Nature · Jun 24, 2026Peer-reviewedBiochemistry

Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy

Natalia Pakharukova, Brittany N. Thomas, Harsh Bansia, Linus Li, Dana K. Bassford, Rinat R. Abzalimov, Jihee Kim, Alem W. Kahsai, Biswaranjan Pani, Kunhong Xiao, Roni Ochakovski, Shibo Liu, Xingdong Zhang, Seungkirl Ahn, Amédée des Georges, Robert J. Lefkowitz

The paper reveals how beta-arrestin 1 activates Src kinase via two distinct SH3 domain interactions, using cryo-EM to show structural mechanisms of beta-arrestin-mediated signaling.

Nature Communications · Feb 20, 2026Peer-reviewedBiochemistry