Author

Alem W. Kahsai

Duke Medical CenterORCID 0000-0001-9272-4484Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Natalia PakharukovaiD· 3 shared Robert J. LefkowitziD· 3 shared Seungkirl AhniD· 3 shared Ali MasoudiiD· 2 shared Brittany N. ThomasiD· 2 shared Dana K. BassfordiD· 2 shared Howard A. RockmaniD· 2 shared Jihee Kim· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiochemistry

Natalia PakharukovaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivPreprintJul 16, 2026

Conformational Basis of Functionally Selective Allosteric Modulation of the Angiotensin II type 1 Receptor by Small Molecules

Samuel Liu, Peng Xiao, Matthias Elgeti…·Robert J. Lefkowitz

The paper identifies and characterizes small molecule allosteric modulators of the AT1R, revealing their conformational mechanisms and effects on G protein and β-arrestin pathways.

DOI 10.64898/2026.07.15.736838

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistryNaturePeer-reviewedJun 24, 2026

Small-molecule modulation of Beta-arrestins

Alem W. Kahsai, Natalia Pakharukova, Henry Y. Kwon…·Robert J. Lefkowitz

This study identifies small-molecule inhibitors of beta-arrestins and elucidates their mechanism, offering a framework for modulating GPCR signaling.

7 citationstop 2%

humanproteomics

𝕏 PostBluesky

BiochemistryNature CommunicationsPeer-reviewedFeb 20, 2026

Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy

Natalia Pakharukova, Brittany N. Thomas, Harsh Bansia…·Robert J. Lefkowitz

The paper reveals how beta-arrestin 1 activates Src kinase via two distinct SH3 domain interactions, using cryo-EM to show structural mechanisms of beta-arrestin-mediated signaling.

9 citationstop 1%

cryo-EMexperimental assay

𝕏 PostBluesky