Anthony J. Garrity

The paper introduces an optical method to link genetic perturbations with phenotypic outcomes in a pooled setting, identifying novel regulators of immune responses.

CloneRetriever identifies and retrieves rare clones from heterogeneous populations to study clonal fitness and selection mechanisms.

Diluting lentiviral perturbation libraries with a carrier plasmid during packaging prevents intermolecular recombination and multiple integrations in pooled screens, although viral titer drops by 100-fold.