Fernando Salgado-Polo

This study discovers potent, selective macrocyclic peptide ligands for CXCR4, a class A GPCR, demonstrating the feasibility of de novo peptide design for this receptor family.

This study shows cholesterol modulates chemokine receptor activity differently, affecting some receptors but not others, and distinguishes cholesterol from oxysterols in their effects.

This study investigates XCR1 internalization and localization mechanisms, revealing AP2-dependent constitutive endocytosis and sequence motifs critical for trafficking.

This study evaluates a type IV ATX inhibitor, Cpd17, showing improved efficacy over a type I inhibitor in reducing liver injury in mouse models of acute liver injury and non-alcoholic steatohepatitis.

This study identifies sequence-dependent trafficking pathways of GDE2 that regulate its function in neuronal differentiation and neurodegeneration.