Etowah Adams

A public crystallographic structure and affinity dataset for enteroviral 2A protease (925 binding events, 699 compounds), with docking, cofolding and screening baselines. Fragment fine-tuning of OpenFold3-p2 improves follow-on predictions.

A 40B-parameter DNA model trained on 9.3 trillion tokens scores coding and noncoding variants zero-shot, exposes interpretable sequence features, and writes chromosome-scale sequences.

The paper trains sparse autoencoders on a protein language model to identify features that represent protein sequences, revealing both generic and family-specific patterns and their potential biological roles.