Author

Ali Ebrahim

City University of New YorkORCID 0000-0003-2661-381XUnclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Ali Ebrahim1 paper

Biology Disciplines

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Biophysics· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:protein structure· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Organism:human· 1

Frequent Co-Authors

Blake T. RileyiD· 2 shared D. A. KeedyiD· 2 shared Aliki PerdikariiD· 1 shared Anthony C. BishopiD· 1 shared Cédric ValléeiD· 1 shared Charlotte Mary DeaneiD· 1 shared Dinesh Singh ShahiD· 1 shared E. Charles AdamsiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

Blake T. RileyORCID

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintSep 1, 2026

✦ In-depth digest

The first OpenBind release: An open experimental structure-affinity dataset and benchmark for structure-based AI

Jochem Nelen, Omeir Khan, E. Charles Adams…·Fergus Imrie

A public crystallographic structure and affinity dataset for enteroviral 2A protease (925 binding events, 699 compounds), with docking, cofolding and screening baselines. Fragment fine-tuning of OpenFold3-p2 improves follow-on predictions.

1 citation

virusprotein structure

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BiophysicsJournal of Biological ChemistryPeer-reviewedOct 23, 2025

Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy

Aliki Perdikari, Virgil A. Woods, Ali Ebrahim…·D. A. Keedy

The paper identifies functional PTP1B variants in thin individuals and uses structural biology to reveal allosteric sites for obesity drug development.

8 citations

humanprotein structure

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BiophysicsProteins Structure Function and BioinformaticsPeer-reviewedJul 5, 2025

Three STEPs forward: A trio of unexpected structures of PTPN5

Liliana Guerrero, Ali Ebrahim, Blake T. Riley…·D.A. Keedy

This study presents three new crystal structures of STEP (PTPN5) revealing unexpected conformational features and ligand binding events that provide insights for structure-based drug design.

2 citations

structural biologyexperimental assay

𝕏 PostBluesky