Jeroen P. Roose

RasGRP1 promotes efficient intestinal tuft cell differentiation

This study identifies RasGRP1 as a regulator of tuft cell differentiation in the intestine, showing it restricts progenitor proliferation and enhances IL-13-driven responses.

Single cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions.

The paper uses single-cell proteomics and metabolomics to study how Ras pathway mutations affect hematopoiesis, finding distinct impacts on HSC compartments and metabolism.

nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer

This study shows that eliminating nSMase2 in pancreatic cancer reduces tumor growth, promotes a less aggressive tumor subtype, and enhances immune responses by altering exosome production and macrophage polarization.