Colin Y.C. Lee

This study shows melanoma suppresses galectin-9 on dendritic cells, and restoring it limits T regulatory cell expansion, suggesting a new therapeutic target.

This study identifies a mechanism by which skull bone marrow-derived HSPCs and CD4+ T cells promote immunotolerance in childhood brain tumours, showing that antibody therapy targeting CSF cytokines can disrupt this process and induce tumour regression.

This study shows that intestinal immunological challenges shape the polarization of dural CD4 T cells, which provide protective memory against pathogens.

MintFlow is a generative AI algorithm that predicts how tissue perturbations reprogram cell states in disease, revealing novel cell populations and therapeutic targets in three human conditions.