Patrick Heun

The paper shows that deletion of roX RNA in Drosophila male cells leads to X chromosome duplication to compensate for dosage imbalance, and full-length roX2 restores normal function.

This paper describes a method to efficiently form single-copy human artificial chromosomes by using a large construct and yeast spheroplast fusion to avoid multimerization.

The paper identifies two DOMINO isoforms in Drosophila that form distinct complexes with different functions: DOM-B acts like SWR1 by depositing H2A.V, while DOM-A acts like NuA4 by acetylating H4K12.