Mario F. Fraga

The paper quantifies epigenetic noise across human tissues using DNA methylation data and finds that mitotic history, not chronological age, is the main driver of noise accumulation.

This study maps chromatin changes at repetitive DNA during aging and cancer using epigenomic data from hematopoietic cells and malignancies.

The paper shows that environmental enrichment modulates age-related changes in the 3D chromatin interactome of mouse hippocampal neurons, inducing maturation in young mice and partial rejuvenation in old mice.

This study links EPAS1HIF2 genetic adaptations in high-altitude populations to similar mutations in hypoxia-driven tumors, showing shared mechanisms in hypoxia response and tumorigenesis.

This study estimates a universal maximum lifespan limit for mammals by analyzing age-related epigenetic entropy in DNA methylation patterns across species.

The paper identifies distinct chromatin signatures associated with DNA hypomethylation in aging and cancer, showing different histone marks in each process.

The paper identifies a novel non-canonical class of aberrant DNA hypermethylation in glioma linked to 5hmC hypo-hydroxymethylation at specific CpG sites.