Age-Dependent Maturation and Rejuvenation of the Neural 3D Chromatin Interactome in Enriched Environments
Javier Gancedo-Verdejo, Rocío G. Urdinguio, Juan Ramón Tejedor, Raúl F. Pérez, Alfonso Peñarroya, Pablo Santamarina‐Ojeda, Annalisa Roberti, Jennifer M. Kefauver, Carlota Álvarez-Díaz, Mar Rodríguez-Santamaría, José Luís Trejo, Laureano Tomás-Daza, Llorenç Rovirosa, Biola M. Javierre, Agustín F. Fernández, Mario F. Fraga
The paper shows that environmental enrichment modulates age-related changes in the 3D chromatin interactome of mouse hippocampal neurons, inducing maturation in young mice and partial rejuvenation in old mice.
Cell Reports · Aug 22, 2025Peer-reviewedGenomics