Agustín F. Fernández

Replicative history as a major determinant of epigenetic noise across human tissues

The paper quantifies epigenetic noise across human tissues using DNA methylation data and finds that mitotic history, not chronological age, is the main driver of noise accumulation.

Repetitive DNA-resolved epigenomics maps chromatin rewiring during aging and malignant transformation

This study maps chromatin changes at repetitive DNA during aging and cancer using epigenomic data from hematopoietic cells and malignancies.

Age-Dependent Maturation and Rejuvenation of the Neural 3D Chromatin Interactome in Enriched Environments

The paper shows that environmental enrichment modulates age-related changes in the 3D chromatin interactome of mouse hippocampal neurons, inducing maturation in young mice and partial rejuvenation in old mice.

Estimating universal mammalian lifespan via age-associated epigenetic entropy

This study estimates a universal maximum lifespan limit for mammals by analyzing age-related epigenetic entropy in DNA methylation patterns across species.

Distinct chromatin signatures of DNA hypomethylation in aging and cancer

The paper identifies distinct chromatin signatures associated with DNA hypomethylation in aging and cancer, showing different histone marks in each process.

Non-canonical aberrant DNA hypermethylation in glioma

The paper identifies a novel non-canonical class of aberrant DNA hypermethylation in glioma linked to 5hmC hypo-hydroxymethylation at specific CpG sites.