Roberta Dı́az Brinton

The paper analyzes brain volume changes in humanized APOE mice across age and genotype, finding age-related increases in total brain volume and no significant sex or genotype differences in localized volume changes.

This study uses MRI to show that humanized APP significantly reduces brain volume in humanized APOE knock-in mice, with hAPOE4 homozygosity exacerbating this effect.

This study shows that APOE4 accelerates menopause-related metabolic decline and impairs bioenergetic adaptation in the brain, increasing Alzheimer's disease risk.

The paper investigates sex and APOE ε4 genotype effects on metabolic alterations in Alzheimer’s disease using stratified analysis of serum metabolites.