Author

Avnish Bhattrai

University of ArizonaORCID 0000-0002-8376-123XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:imaging· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Adam C. RaikesiD· 2 shared Roberta Dı́az BrintoniD· 2 shared Jean‐Paul L. WiegandiD· 1 shared Tian WangiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersNeuroscience

Adam C. RaikesORCID

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2 papers

Recent·Most cited

NeuroscienceFrontiers in NeurosciencePeer-reviewedJul 14, 2026

Humanized APOE mouse brain volume increases over age irrespective of sex and APOE genotype: Implications for translational validity to the human

Adam C. Raikes, Avnish Bhattrai, Tian Wang…·Roberta Dı́az Brinton

The paper analyzes brain volume changes in humanized APOE mice across age and genotype, finding age-related increases in total brain volume and no significant sex or genotype differences in localized volume changes.

2 citationstop 4%

mouseimaging

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NeuroscienceAlzheimer s & Dementia Translational Research & Clinical InterventionsPeer-reviewedJul 1, 2026

Humanized APP is the primary determinant of regional brain volume in humanized APOE knock-in mice: a cross-sectional ex vivo MRI study

Avnish Bhattrai, Adam C. Raikes, Roberta Dı́az Brinton

This study uses MRI to show that humanized APP significantly reduces brain volume in humanized APOE knock-in mice, with hAPOE4 homozygosity exacerbating this effect.

DOI 10.1002/trc2.70325

mouseimaging

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