Author

Adam C. Raikes

University of ArizonaORCID 0000-0002-1609-6727Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:imaging· 3 Approach:statistical model· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1 Approach:experimental assay· 1

Frequent Co-Authors

Roberta Dı́az BrintoniD· 3 shared Avnish BhattraiiD· 2 shared Ai Wern ChungiD· 1 shared Andrew L. AlexanderiD· 1 shared Bennett A. LandmaniD· 1 shared Camila Boneu· 1 shared Christopher D. SmyseriD· 1 shared Damien A. FairiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersNeuroscience

Roberta Dı́az BrintonORCID

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4 papers

Recent·Most cited

Humanized APOE mouse brain volume increases over age irrespective of sex and APOE genotype: Implications for translational validity to the human

Adam C. Raikes, Avnish Bhattrai, Tian Wang, Jean‐Paul L. Wiegand, Roberta Dı́az Brinton

The paper analyzes brain volume changes in humanized APOE mice across age and genotype, finding age-related increases in total brain volume and no significant sex or genotype differences in localized volume changes.

Frontiers in Neuroscience · Jul 14, 2026Peer-reviewedNeuroscience

Humanized APP is the primary determinant of regional brain volume in humanized APOE knock-in mice: a cross-sectional ex vivo MRI study

Avnish Bhattrai, Adam C. Raikes, Roberta Dı́az Brinton

This study uses MRI to show that humanized APP significantly reduces brain volume in humanized APOE knock-in mice, with hAPOE4 homozygosity exacerbating this effect.

Alzheimer s & Dementia Translational Research & Clinical Interventions · Jul 1, 2026Peer-reviewedNeuroscience

White matter micro- and macrostructural properties in midlife individuals at risk for Alzheimer's disease: Associations with sex and menopausal status

Adam C. Raikes, Jonathan P. Dyke, Matilde Nerattini, Camila Boneu, Trisha Ajila, Francesca Fauci, Michael Battista, Silky Singh Pahlajani, Schantel Williams, Roberta Dı́az Brinton, Lisa Mosconi

Scientific Reports · Nov 17, 2025Peer-reviewedNeuroscience

Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications

Matthew Cieslak, Mustafa Okan Irfanoglu, Steven L. Meisler, Taylor Salo, Adam C. Raikes, Philip A. Cook, Ai Wern Chung, Erik G. Lee, Ruolin Li, Xu Li, Diliana Pecheva, Damien A. Fair, Christopher D. Smyser, Michael P. Harms, Bennett A. Landman, , Theodore Daniel Satterthwaite

The paper describes improvements in diffusion MRI processing for the HBCD study, introducing new software and observing developmental patterns in brain data.

bioRxiv · Nov 10, 2025 · PreprintNeuroscience