Dimitrios G. Stamou

This study shows LAT condensation gates PLCγ1 activation through bimodal LAT phosphorylation, enhancing signal amplification and noise suppression in T cells.

This study uses single-molecule recordings to show Ca2+-ATPases switch between active and inactive modes, revealing a new regulatory mechanism for Ca2+ homeostasis.

This study shows that V-ATPase inhibitors block mode-switching between active and inactive states without affecting proton transport rates.

This paper quantifies GPCR intrinsic activation at the plasma membrane, revealing spatial multimodality with most receptors showing negligible spontaneous activation.