Arup K. Chakraborty

This study shows LAT condensation gates PLCγ1 activation through bimodal LAT phosphorylation, enhancing signal amplification and noise suppression in T cells.

This study shows that IgD's long hinge increases entropic cost in antigen binding, reducing negative selection and raising the threshold for germinal center entry.

The paper investigates how active RNA synthesis influences nuclear condensate patterning by studying nucleolar fibrillar centers and shows that RNA synthesis affects their size, number, and spacing.

The paper develops a mathematical model to study how immune responses and metabolic pathway adaptations interact during infection, finding that glucose redistribution and cytokine regulation are critical for effective pathogen clearance.

This study uses computational modeling to show that broadly neutralizing antibodies (bnAbs) promote the evolution of diverse autologous antibodies that target multiple HIV spike epitopes, potentially enabling viral control.

This paper develops two models to explain LAT condensate formation in reconstitution experiments, showing that condensate morphologies arise from common dynamics modulated by experimental conditions.

The paper investigates how RNA gradients influence protein condensate motion toward promoters, showing implications for enhancer-promoter contacts and condensate-promoter interactions.

The paper designs mosaic nanoparticles with SARS-like betacoronavirus RBDs to enhance cross-reactive immune responses in mice, finding that mosaic-7COM elicits stronger responses against zoonotic sarbecoviruses and Omicrons.

This study identifies enhancer features that drive transcriptional condensate formation through phase separation mechanisms involving TF binding site valency, density, and affinity.